Yt antigen system

Yt antigen system

The Yt antigen system (also known as Cartwright) is present on the membrane of red blood cells and helps determine a person's blood type. The antigens are found on the protein acetylcholinesterase, an enzyme which helps break down acetylcholine. [Bartels CF, Zelinski T, Lockridge O. "Mutation at codon 322 in the human acetylcholinesterase (ACHE) gene accounts for YT blood group polymorphism." Am J Hum Genet. 1993 May;52(5):928-36. PMID 8488842 ] The Yt system features two alleles, Yt(a) and Yt(b). Antibodies against the Yt system can lead to transfusion reactions such as hemolytic anemia.

References

OMIM|112100 - OMIM page on Yt antigen

External links

* [http://www.ncbi.nlm.nih.gov/projects/mhc/xslcgi.fcgi?cmd=bgmut/systems_info&system=yt Yt at BGMUT] Blood Group Antigen Gene Mutation Database at NCBI, NIH


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